Fatty Acid Synthesis – Part I

Author Since: Mar 11, 2019

  1. Who gives a shit about what her voice sounds like. Don't like it, watch a different one. Thank you for making it easy to understand.

  2. OAA is not converted directly to pyruvate, but first converted to malate which is the converted to pyruvate through malate dehydrogenase, and only in this reaction we earn that nadph you were talking about. 

  3. I wanna say a HUGE THANKS to you jasmine. I totally depend on all your video for my college biochemistry courses!!! YOU ARE AWESOME:)))))

  4. Since you mentioned that fatty acids can be obtained from the 3 sources, so why does the body still need to make fatty acids?

  5. I can't get past the first 30 seconds… so when I find that Khan's not doing these videos, I just go back the way I came in. It would be fine if I wasn't so damn sure she's faking it. Stop slurring and get it together woman!

  6. thanks for the awesome videos, I have one question though; what's the enzyme that breaks the citrate into OAA and Acetyl-coA?

  7. Didn't we just lose an OAA from the Kreb Cycle? OAA gets combined with Acetyl-co-A to form Citrate, which is moved out of the mitrochondria.
    How can it cycle, if it loses one of the key components of the cycle?

  8. It should be noted that citrate does not contain acetyl-CoA, but simply acetyl. So the CoA-group is added to the citrate in the cytosol by the means of ATP-citrate lyase after the citrate is transported into the cytosol.

  9. It is not pyruvate dehydrogenase but it is pyruvate dehydrogenase complex, because it is made from 3 enzymes subunits.

  10. Thanks for your excellent videos. Can you very kindly clarify the following. Can dietary fat only be burnt by mitochondria if it has first been ‘processed through’ fat cells and released as FFA? Or can mitochondria also burn dietary fat that hasn’t come from a fat cell? Thanks for any comments.

  11. It's perfect!! Whoever disliked this video, I got news for you: You're not going to simplify this very complicated topic any better than this already.

  12. I thought the reaction of converting pyruvate to OAA is irreversible. How do we make pyruvate from OAA? using a different pathway I reckon?

  13. So when you consume fat from your diet, it eventually gets into your blood stream via chylomicrons. Can the triglycerides be then stored directly as fat in your adipose tissue? Or does it have to first go through glycolysis and turn into Acetyl-CoA and then back to Triglycerides via Fatty Acid Synthesis?

  14. So this ENTIRE video is about Glycolysis –> Kreb's Cycle –> Citrate shuttled to cytoplasm –> lysed into OAA+Acetyl-CoA. OAA +NADP+ –> CO2 + Pyrvuate + NADPH. Her reasoning for doing this entire video was that NADPH and Acetyl CoA are used in fatty acid synthesis. Don't waste your time watching this entire video if you know what Glycolysis and Krebs are. Just take out that the Krebs produces citrate which can go to the cytoplasm and be converted into the substrates of interest: Acetyl CoA + NADPH.

  15. What really floats my boat is when people use the singular, mitochondrion. Surely mitochondria don't always need to be plural.

  16. I like the lesson … but OMG the voice !! I end up reading the transcript , sorry but your voice is very irriting and I am already suffering from misophonia … why you trying to be sexy any way!!!

  17. overall its a good video but u r speaking really fast so its difficult for me to get some words..overall nice experience

  18. the pyrovate molecules convert to AcetylcoA before entering the mitochondria
    and thank you it was such a good video

  19. you'd better not keep the pen moving without any indication which could bother us, because we are always concentrating on your voice and the pen all the time. anyway the video is still great! thanks!

  20. Love the charisma, but you’re teaching physiology, not selling real estate to adolescent boys. PS it’s pronounced ^sub^-sequently.

  21. This comment section is divided between people who absolutely despise her voice and people who are wayyy too seduced by it…. get it together people lmao

  22. Wasting too much time on the Krebs cycle (3 minutes from 5:00–8:00, so if you know it you can skip over), that is covered in numerous videos already.

  23. This was so helpful, thanks! I agree with the small already made suggestions of clarifying that citrate doesn't actually contain acetyl-CoA but acetyl itself and also that the pdh is a complexe. also i've never heard of the nadph // oxalacetat –> pyruvat conversion. Instead I was taught that there is an exchange between malat and oxalacetat?
    Anyways, those are just minor things – and your voice is not annoying at all! I personally think it's super important for these rather long videos to not be to monotone. Without proper enunciation, which you clearly delivered, it just get's lenghty. Keep it up!

  24. 2:05….post meal.insulin drops and glucagon rises 1-2hours after a meal (thats correct)
    BUT glucagon's main effect is on liver not on adipose..Epinephrine and cortisol are the ones that mainly stimulate HSL in adipose(lipolysis) 🙂

  25. I was feeling super good about my understanding of these processes, and then she says NADPH and, well… I suppose it's back to studying. :/

  26. Damn she looks like she's trying to seduce the viewers this is very annoying.Maybe she was missing her boyfriend at that time

  27. I really needed help on this topic….but I just can't stand your voice….wtf is wrong with your voice……fix it, woman…..drink some water!!!

  28. Requiring a citrate shuttle in order to get the acetyl-coA from mitochondria out into the cytoplasm seemed like a waste until we realized that once it breaks down to OAA and then to pyruvate, we get NADPH, which is essential to FA synthesis. The cell is such a well oiled machine!