Old human cells rejuvenated with stem cell technology


Old human cells return to a more youthful
and vigorous state after being induced to briefly express a panel of proteins involved
in embryonic development, according to a new study by researchers at the Stanford University
School of Medicine. The researchers also found that elderly mice
regained youthful strength after their existing muscle stem cells were subjected to the rejuvenating
protein treatment and transplanted back into their bodies. The proteins, known as Yamanaka factors, are
commonly used to transform adult cells into induced pluripotent stem cells, or iPS cells. Induced pluripotent stem cells can become
nearly any type of cell in the body, regardless of the cell from which they originated. They’ve become important in regenerative
medicine and drug discovery. The study found that inducing old human cells
in a lab dish to briefly express these proteins rewinds many of the molecular hallmarks of
aging and renders the treated cells nearly indistinguishable from their younger counterparts.

Author Since: Mar 11, 2019